Breaths, Twists, and Turns of Atomistic Nucleosomes

Twists and turns

Computational modelling of the heart tube during development reveals the interplay between tissue asymmetry and growth that helps our hearts take shape.

The twists and turns of enzyme function.

Twists and turns in protein folding

to make the best possible use of the bounty of genome information that is becoming available at an ever increasing pace. If only one could feed each new sequence into a computer and let it wriggle the polypeptide chain about in silico, to see what three-dimensional structure it ends up with, the proteins encoded by the genomes already sequenced would soon become an open book. But sadly, althoug...

Acrosomal Actin: Twists and Turns of a Versatile Filament

A new electron cryomicroscopic reconstruction of an actin-scruin bundle from Limulus sperm reveals details about the enormous structural plasticity within F-actin. The twist and tilt of the actin subunits show very large deviations from ideal F-actin, providing clues about actin dynamics.

Regulation of Plexin: A Ring of Structural Twists and Turns

The regulation of the guidance receptor plexin is incompletely understood. In this issue, Kong et al. (2016) present crystal structures of the full-length extracellular region of class A plexins, revealing its dual role in both autoinhibition and activation.